Always inform your doctor or pharmacist of all medications you’re taking, including over-the-counter drugs and supplements, before starting Domperidone. This helps prevent potentially harmful interactions.
Specific Medications to Note
- Strong CYP3A4 inhibitors (like ketoconazole, erythromycin, ritonavir): These can increase Domperidone levels, raising the risk of side effects. Your doctor may adjust your Domperidone dose or choose a different medication. Certain antidepressants (some SSRIs and SNRIs): Concomitant use may increase the risk of QT prolongation, a heart rhythm abnormality. Careful monitoring is necessary. Drugs that prolong the QT interval (such as amiodarone, sotalol): Combined use with Domperidone significantly increases the risk of dangerous heart rhythm disturbances. Alternative treatment should be considered.
Herb-Drug Interactions
Some herbal remedies, particularly those containing St. John’s Wort, can interact with Domperidone. Discuss all herbal supplements with your healthcare provider before taking them with Domperidone.
Recommendations
Maintain a complete and updated list of all your medications. Provide this list to every healthcare professional you see. Report any unusual side effects immediately to your doctor. Never adjust your Domperidone dosage without consulting your doctor.
Further Information
This information is not exhaustive. For complete details about potential drug interactions, consult your physician or a qualified pharmacist. They can provide personalized advice based on your specific health conditions and medications.


